To Be Targeted: Is the Magic Bullet Concept a Viable Option for Synthetic Nucleic Acid Therapeutics?

Human Gene Therapy. Ahead of print. doi:10.1089/hum.2011.065.

Manfred Ogris and Ernst Wagner.
Pharmaceutical Biotechnology, Ludwig Maximilians University, Munich 81377, Germany.

Keywords: Nucleic acids, genetic disorders, infectious diseases, cancer, viral vectors, synthetic delivery systems, receptor targeting of synthetic vectors, improve the specificity, increase the efficiency of nucleic acid delivery.