Dual role of the mitochondrial protein frataxin in astrocytic tumors

Laboratory Investigation , (22 August 2011) | doi:10.1038/labinvest.2011.130

Elmar Kirches, Nadine Andrae, Aline Hoefer, Barbara Kehler, Kim Zarse, Martin Leverkus, Gerburg Keilhoff, Peter Schonfeld, Thomas Schneider, Annette Wilisch-Neumann and Christian Mawrin

Keywords: frataxin (FXN), mitochondrial iron homeostasis, iron–sulfur cluster biogenesis, electron transport chain, reactive oxygen species (ROS), Friedreich's ataxia, suggest a dual, pro-proliferative but chemosensitizing role in astrocytic tumors.