A Drosophila Model of Friedreich's Ataxia and Autophagic Heart Disease.

Wayne State Univ, ?.

Luan Wang. Inst Environmental Hlth Sci, Wayne State Univ, Detroit, MI.

Keywords: Friedreich’s Ataxia (FRDA), Drosophila model for FRDA, UAS-Gal4 system, heart (tinman), neurons (elav), whole body (actin and daG32), reactive oxygen species (ROS) reagent, oxidative stress, autophagy activity.

"This suggests that there is a threshold for frataxin level to maintain the normal function."