Iron and Diabetes Risk

Iron and Diabetes Risk, Judith A. Simcox, Donald A. McClain; Cell Metabolism, Volume 17, Issue 3, 5 March 2013, Pages 329-341, http://dx.doi.org/10.1016/j.cmet.2013.02.007

Friedreich ataxia is associated with increased prevalence of type 2 diabetes. Abnormal IRP1 activity is seen in patients with Friedreich ataxia. It's thought frataxin is an iron chaperone or storage protein. IRP1 aconitase activity is decreased, while IRP binding to IREs is increased.