Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity

Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity. Frida Loría, Javier Díaz-Nido, Neurobiology of Disease, Available online 29 December 2014, ISSN 0969-9961, http://dx.doi.org/10.1016/j.nbd.2014.12.017.

Findings confirm a detrimental effect of frataxin silencing, not only for astrocytes, but also for neuron-glia interactions, underlining the need to take into account the role of non-cell autonomous processes in FA.