Selective dendritic susceptibility to bioenergetic and redox perturbations in cortical neurons

Selective dendritic susceptibility to bioenergetic and redox perturbations in cortical neurons. Philip Hasel, Sean Mckay, Jing Qiu, Giles E. Hardingham; Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Available online 22 December 2014, ISSN 0167-4889, http://dx.doi.org/10.1016/j.bbamcr.2014.12.021.

Deregulation of glutathione homeostasis and other antioxidant systems is implicated in the aetiology of several neurodegenerative disorders associated with dendritic pathologies, including: Alzheimer's disease, Huntington's disease, ALS Friedreich's ataxia, and Parkinson's disease, and activation of GSH pathway enzymes, particularly in astrocytes, is a potential therapeutic strategy for combating oxidative stress in the brain.