Nonneurological Involvement in Late-Onset Friedreich Ataxia (LOFA): Exploring the Phenotypes

Alberto R. M. Martinez, Adriana Moro, Agessandro Abrahao, Ingrid Faber, Conrado R. Borges, Thiago J. R. Rezende, Carlos R. MartinsJr, Mariana Moscovich, Renato P. Munhoz, Sandra Leistner Segal, Walter O. Arruda, Maria Luiza Saraiva-Pereira, Simone Karuta, José Luiz Pedroso, Anelyssa D’Abreu, Laura B. Jardim, Íscia Lopes-Cendes, Orlando G. Barsottini, Hélio A. G. Teive, Marcondes C. França Jr; Cerebellum. 2016 Jan 11. [Epub ahead of print] DOI:10.1007/s12311-015-0755-8

"LOFA" contradicts several of the classical clinical features of FDRA by this reaon is an important diagnostic challenge for general neurologists

Some interesting data on prevalence: In this study LOFA cases accounted for 17 % of the FDRA patients (Brasil). Other studies found 17 % of LOFA prevalence, and in other the prevalence of LOFA patients ranged from 13.5 to 25%.


 Nonneurological Involvement in Late-Onset Friedreich Ataxia (LOFA): Exploring the Phenotypes