Progression of Friedreich ataxia: quantitative characterization over 5 years

Patel, M., Isaacs, C. J., Seyer, L., Brigatti, K., Gelbard, S., Strawser, C., Foerster, D., Shinnick, J., Schadt, K., Yiu, E. M., Delatycki, M. B., Perlman, S., Wilmot, G. R., Zesiewicz, T., Mathews, K., Gomez, C. M., Yoon, G., Subramony, S. H., Brocht, A., Farmer, J. and Lynch, D. R. (2016), Annals of Clinical and Translational Neurology. doi: 10.1002/acn3.332

Open access article (Creative Commons Attribution-NonCommercial-NoDerivs License)

Objective: Friedreich ataxia (FRDA) is a progressive neurodegenerative disorder of adults and children. This study analyzed neurological outcomes and changes to identify predictors of progression and generate power calculations for clinical trials.

 Progression of Friedreich ataxia: quantitative characterization over 5 years