Genome damage from CRISPR/Cas9 gene editing higher than thought

ScienceDaily, 19 July 2018. Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

Journal Reference:

Michael Kosicki, Kärt Tomberg, Allan Bradley. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements. Nature Biotechnology, 2018; DOI: 10.1038/Nbt.4192

 Genome damage from CRISPR/Cas9 gene editing higher than thought