Transcriptional profiling of isogenic Friedreich ataxia induced pluripotent stem cell-derived neurons

Jiun-I Lai, Daniel Nachun, Lina Petrosyan, Benjamin Throesch, Erica Campau, Fuying Gao, Kristin K Baldwin, Giovanni Coppola, Joel M Gottesfeld, Elisabetta Soragni; bioRxiv 457093; doi: 10.1101/457093

We find that multiple cellular pathways are commonly affected by the loss of frataxin in CNS and peripheral nervous system neurons and these changes are partially restored by HDACi treatment.

Transcriptional profiling of isogenic Friedreich ataxia induced pluripotent stem cell-derived neurons