Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Louisa P. Selvadurai Louise A. Corben Martin B. Delatycki Elsdon Storey Gary F. Egan Nellie Georgiou‐Karistianis Ian H. Harding. Hum Brain Mapp. 2020; 1– 14. doi:10.1002/hbm.24921

For the first time, we examined the relative sensitivity and relationship between multiple white matter indices in Friedreich ataxia to more richly characterize disease expression and infer possible mechanisms underlying the observed white matter abnormalities.
Multiple mechanisms likely underpin white matter abnormalities in Friedreich ataxia, with differential impacts in cerebellar and cerebral pathways.

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study