The model simulations revealed that the feedback delay, but not the feedback gain was affected in FA patients. They also showed that the descending control signal was scaled in time and amplitude and co-contraction was smaller in FA patients. Thus, our study explains how the motor deficits of FA patients result from pathological alterations of both top-down and feedback control.
Wednesday, March 16, 2022
Control of arm movements in Friedreich's ataxia patients: role of sensory feedback
Zhang L, Straube A, Eggert T. ; Exp Brain Res. 2022 Mar 14. doi: 10.1007/s00221-022-06343-5. Epub ahead of print. PMID: 35286422.
