Tuesday, December 27, 2022

Gambling associated risk-taking decision in cerebellar ataxia

Ruo-Yah Lai Natasha A. Desai Christian J. Amlang Chi-Ying R. Lin Tiffany X. Chen Michael J. Minyetty Nadia Amokrane Sheng-Han Kuo;  Parkinsonism & Related Disorders, Volume 0, Issue 0, 105252,  doi:10.1016/j.parkreldis.2022.105252 

People with cerebellar ataxia (CA) can develop impulsive and compulsive behaviors that significantly affect their and their family's quality of life. To further assess the decision-making process associated with these behaviors, we used the Iowa Gambling Task (IGT) to study people with CA.
CA cases obtained significantly lower IGT total scores than controls (−5.30 ± 37.53 vs. 21.30 ± 37.37, p = 0.004). In addition, those with CA made riskier decisions throughout the task compared to controls. Although both CA and controls learned to make decisions with more favorable outcomes over the course of completing the IGT, CA participants never matched the controls' performance. IGT performance did not correlate with ataxia severity or depressive symptoms.