We show that fixel-based analysis of diffusion MRI data is particularly sensitive to longitudinal change in the cerebellar peduncles, as well as motor and sensory white matter tracts. In combination with other morphometric measures, they may therefore provide sensitive imaging biomarkers of disease progression for clinical trials.
Monday, August 7, 2023
Brain MRI detects early-stage alterations and disease progression in Friedreich ataxia
Adanyeguh IM, Joers JM, Deelchand DK, et al. Brain MRI detects early-stage alterations and disease progression in Friedreich ataxia. Brain Communications. 2023 ;5(4):fcad196. DOI: 10.1093/braincomms/fcad196. PMID: 37483529.
