Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice

Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice Enrico M Novelli, Shane Lenhart, Lesley M Foley, Nandinii Sekar, Paritosh Mondal, Hong Wang, T Kevin Hitchens, Samit Ghosh, Stephen Y Chan, Xiaoming Hu, Rimi Hazra, bioRxiv 2024.12.20.629760; doi:10.1101/2024.12.20.629760

Pharmacological induction of FXN by administration of insulin growth factor-1 improved cognitive function in the SSFXN-KO mice. Overall, our data demonstrate that FXN is a critical factor regulating neuroaxonal health and cognitive function in SCD mice. FXN may therefore be a novel pharmacologic target to prevent cerebrovascular complications in SCD.

Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice