Idebenone Induces Apoptotic Cell Death in the Human Dopaminergic Neuroblastoma SHSY-5Y Cells.

Neurotox Res. 2011 May 3. [Epub ahead of print]

Tai KK, Pham L, Truong DD.

The Parkinson's and Movement Disorder Research Laboratory, Long Beach Memorial Medical Center, 2801 Atlantic Ave., Long Beach, CA, USA

Keywords: Idebenone, coenzyme Q10 analog, antioxidant, Friedreich Ataxia, neurodegenerative diseases, Parkinson's disease, dopaminergic neuroblastoma SHSY-5Y cells, Idebenone-induced cell death, genomic DNA fragmentation, accumulation of cytochrome c, apoptotic. protein BAX, caspase-3, high concentrations.