Myelin paucity of the superior cerebellar peduncle in individuals with Friedreich ataxia: an MRI magnetization transfer imaging study

Myelin paucity of the superior cerebellar peduncle in individuals with Friedreich ataxia: an MRI magnetization transfer imaging study. Louise A. Corben, Saman Rassaei Kashuk, Hamed Akhlaghi, Sharna Jamadar, Martin B. Delatycki, Joanne Fielding, Beth Johnson, Nellie Georgiou-Karistianis, Gary F. Egan, Journal of the Neurological Sciences, Available online 1 June 2014, ISSN 0022-510X, http://dx.doi.org/10.1016/j.jns.2014.05.057.

This is the first study to demonstrate reduced MTR in the SCP of individuals with FRDA when compared to control participants. These findings may reflect a process of disruption of the reciprocal relationship between oligodendrocytes and axons resulting in paucity of myelin, and provides significant new insight into the neurodegenerative pathology of FRDA