Photoinduced Transformation of Iron Chelator Deferiprone: Possible Implications in Drug Metabolism and Toxicity

Photoinduced Transformation of Iron Chelator Deferiprone: Possible Implications in Drug Metabolism and Toxicity. V.A. Timoshnikov, V.I. Klimentiev, N.E. Polyakov, G.J. Kontoghiorghes, Journal of Photochemistry and Photobiology A: Chemistry, Available online 2 June 2014, ISSN 1010-6030, http://dx.doi.org/10.1016/j.jphotochem.2014.05.012.

Thefindings suggest that high dose of sunlight might cause chemical modifications which may have chemical, biochemical, pharmacological and toxicological implications, especially possible undesirable phototoxic effects in patients undergoing treatment in countries with increased sunlight exposure.