A missed Fe-S cluster handoff causes a metabolic shakeup

Olivier Berteau; The Journal of Biological Chemistry 293, 8312-8313. doi: 10.1074/jbc.H118.002883

these findings hold significance for the biochemical and medical communities because the cellular phenotype induced mirrors pathological conditions encountered, for example, in nonadipose tissues such as heart and liver with possible connections to Friedreich's ataxia, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis. Further research at the intersection between Fe-S cluster biogenesis and cellular metabolism is thus more than likely to bring unexpected insights into the pathogenesis of poorly understood diseases.

 A missed Fe-S cluster handoff causes a metabolic shakeup