Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells

Daniel R. Crooks, Nunziata Maio§, Andrew N. Lane, Michal Jarnik, Richard M. Higashi, Ronald G. Haller, Ye Yang, Teresa W-M. Fan, W. Marston Linehan and Tracey A. Rouault; The Journal of Biological Chemistry 293, 8297-8311. doi: 10.1074/jbc.RA118.001885

Elucidation of the mechanisms of citrate and lipid droplet accumulation in nonadipose tissues during disease states may reveal important insights into the pathogenesis of a significant number of poorly understood diseases.

 Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells