Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich’s ataxia patients

Daniel Nachun, Fuying Gao, Charles Isaacs, Cassandra Strawser, Zhongan Yang, Deepika Dokuru, Victoria Van Berlo, Renee Sears, Jennifer Farmer, Susan Perlman, David R Lynch, Giovanni Coppola; Human Molecular Genetics, ddy198, doi:10.1093/hmg/ddy198

We identified a transcriptional signature strongly enriched for an inflammatory innate immune response. Future studies should seek to further characterize the role of peripheral inflammation in FRDA pathology and determine its relevance to overall disease progression.

 Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich’s ataxia patients