Non-B DNA structures as a booster of genome instability

Renée C. Duardo, Federico Guerra, Simona Pepe, Giovanni Capranico, Non-B DNA structures as a booster of genome instability, Biochimie, 2023, ISSN 0300-9084, doi:10.1016/j.biochi.2023.07.002.

Transcription-dependent R-loops can also alter the expression levels of genes involved in various disorders. For example, it has been reported that R-loops cause gene silencing at expanded trinucleotide repeats at FXN and FMR1 genes consequently proving an R-loop role in Friedreich's ataxia and X fragile syndrome. Anyway, transcription-mediated R-loop harmful effects are mostly related to the replication process.

Non-B DNA structures as a booster of genome instability