Structure and mechanism of mitochondrial electron transport chain

Runyu Guo, Jinke Gu, Shuai Zong, Meng Wu, Maojun Yang, Biomedical Journal, Available online 26 March 2018, ISSN 2319-4170, doi:10.1016/j.bj.2017.12.001.

For the first time, this work provided solid evidence for the existence of megacomplex, observed the possible compartment of Q pool, and connected the organization of respiratory chain more tightly with the shape of cristae. Since this is the first structure of human respirasome, previously reported mitochondrial disease related mutations can all be mapped into our structure. Doubtlessly, this is a great step forward into conquering many severe neurodegenerative diseases, including Alzheimer's syndrome, Parkinson's disease, multiple sclerosis, friedreich's ataxia, Amyotrophic lateral sclerosis, etc.

 Structure and mechanism of mitochondrial electron transport chain