Cerebellar pathology in Friedreich’s ataxia: Atrophied dentate nuclei with normal iron content

Cerebellar pathology in Friedreich’s ataxia: Atrophied dentate nuclei with normal iron content; K. Solbach, O. Kraff, M. Minnerop, A. Beck, L. Schöls, E.R. Gizewski, M.E. Ladd, D. Timmann; NeuroImage: Clinical, Available online 23 August 2014, ISSN 2213-1582, http://dx.doi.org/10.1016/j.nicl.2014.08.018.

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Applying in vivo MRI methods we could demonstrate significant atrophy of the DN in the presence of normal iron content. The findings suggest that relaxation rates are not reliable biomarkers in clinical trials evaluating the potential effect of FA therapy.