Oxidative stress in neurological disease: Is it the cause, consequence, or trigger of a chronic progressive form?

J.A. Serra, E.R. Marschoff, R.O. Domínguez, Neurología (English Edition), Available online 17 June 2016, ISSN 2173-5808, doi:10.1016/j.nrleng.2016.06.003.

Systemic oxidative stress (OS) is basically an imbalance between the production of such oxi-dants as reactive oxygen species (ROS) and reactive nitrogenspecies (RNS), and the capacity to neutralise their detrimental effects through both exogenous (diet and medication) and endogenous antioxidants.
Systemic OS is increased in such entities as Alzheimer disease(AD), Parkinson’s disease (PD), amyotrophic lateral sclero-sis (ALS), chronic vascular encephalopathy (CVE), epilepsy,and Friedreich ataxia, among others. Reaching a balance between ROS andantioxidants may possibly diminish the risk of progression of these entities. Therefore, an emphasis should be made on the development of pharmacological studies aimed atminimising systemic OS.


 Oxidative stress in neurological disease: Is it the cause, consequence, or trigger of a chronic progressive form?