Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes

Basov, A.; Fedulova, L.; Vasilevskaya, E.; Dzhimak, S. ; Molecules 2019, 24, 4101. doi:10.3390/molecules24224101

Data on the efficacy and metabolic pathways of the therapy also considered 2H-modified drinking and diet for some diseases, such as Alzheimer’s disease, Friedreich’s ataxia, mitochondrial disorders, diabetes, cerebral hypoxia, Parkinson’s disease, and brain cancer.
The effect of isotope exchange on catalytic complexes in some organelles (mitochondria, peroxisome, and lysosome) can change the intensity of metabolic processes at the cellular level as well as substantially modify the resistance or response of biological tissue.
Friedreich’s ataxia was treated by deuterated linoleic and α-linolenic acids, which resulted in rescue of oxidative-stress-challenged cells by decreasing lipid peroxidation, and also deuterated ethyl linoleate (RT001), which recovered mitochondrial function.

Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes