Students Invite Chemists Everywhere To Help With Orphaned Drugs, Diseases

Medical News Today, 21 Oct 2009

Suppose you had a disease for which there's a proven cure, but nobody makes the drug. Where do you turn?

The Cure for Needy Project (http://www.cureforneedy.org)

Redox Control of the Cell Cycle in Health and Disease

Online Ahead of Print: October 21, 2009
Ehab H. Sarsour, Maneesh G. Kumar, Leena Chaudhuri, Amanda L. Kalen, Prabhat C. Goswami, Jurgen Bernhagen, Claudia Castro, Peter M. Chumakov, Tohru Fukai, Fuyuki Ishikawa, Hugo Monteiro, Hasan Mukhtar, Mark Smith, Rhian Touyz. Antioxidants & Redox Signaling. doi:10.1089/ars.2009.2513.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa.

Keywords: reactive oxygen species (ROS), second messengers, quiescence (G0),proliferation (G1, S, G2, and M), cancer, wound healing, fibrosis, cardiovascular diseases, diabetes, and neurodegenerative diseases.

Children With Brain-Damage Often Have Cold Feet

Medicalnewstoday, Article Date: 21 Oct 2009

Many wheelchair-using children with neurological disorders have much colder hands and feet than other children, and most receive no special help even though they have had these problems for a long time, is revealed in at thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden.
(read more)

Inherited Neuromuscular Diseases (book )

Translation from Pathomechanisms to Therapies
Series: Advances in Experimental Medicine and Biology , Vol. 652

Espinós, Carmen; Felipo, Vicente; Palau, Francesc (Eds.)

2009, XIII, 304 p., Hardcover

ISBN: 978-90-481-2812-9

Keywords: muscular dystrophies, mitochondrial disorders, peripheral neuropathies, spinal muscular atrophy, motoneurone disease, Friedreich ataxia, genetics, neuromuscular disorders, peripheral nervous system, cellular biology, pathomechanisms, therapies and treatments.

Idebenone Appears Safe in Patients With Friedreich's Ataxia: Presented at ANA

Doctor's Guide Publishing Limited.

Presentation title: SNT-MC17/Idebenone to Treat Friedreich's Ataxia: Preliminary Phase 3 Safety Data. Poster T-80]

Keywords: blinded interim safety analysis, Friedreich's ataxia, clinical trial, idebenone, severe events, supraventricular extrasystole, reduced visual acuity, fatigue, anxiety, flatulence/abdominal discomfort, electrocardiograms, vital signs, laboratory test, SNT-MC17, headache, nausea, diarrhoea, vomiting, abdominal pain, upper abdominal pain, fatigue, hypercholesterolaemia, rash, flatulence, pruritus.

The N-terminus of mature human frataxin is intrinsically unfolded

FEBS Journal, Early View (Articles online in advance of print)
Published Online: 16 Oct 2009
Journal compilation © 2009 Federation of European Biochemical Societies

Filippo Prischi 1 , Clelia Giannini 2 , Salvatore Adinolfi 3 and Annalisa Pastore 3
1 Dipartimento di Biologia Molecolare, University of Siena, Siena, Italy
2 Dipartimento di Chimica Organica ed Industriale, University of Milano, Italy
3 National Institute for Medical Research, MRC, The Ridgeway, London, UK

KEYWORDS: dynamics, Friedreich's ataxia, IUPs, NMR, structure, Frataxin, mitochondrial protein, neurodegenerative disease, globular domain, N-terminal, unfolded, iron-binding.

Scientists Map First Complete Human Epigenome, The Driver Of Gene Expression

Scientists Map First Complete Human Epigenome, The Driver Of Gene Expression
Genetics News From Medical News Today
When scientists mapped the DNA sequence of 3 billion bases in the human genome they uncovered the master blueprint of what makes a human being; now a team in the US has produced a high resolution map of the first complete human epigenome, the driver of gene expression that regulates how all the options offered in the genome are put together to make the unique person that grows in a particular environment.

Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria

ScienceDaily (Oct. 15, 2009) — All of life is founded on the interactions of millions of proteins. These are the building blocks for cells and form the molecular mechanisms of life. The problem is that proteins are extremely difficult to study, particularly because there are so many of them and they appear in all sizes and weights. Now, Kris Gevaert from VIB/Ghent University and colleagues from the universities of Freiburg and Bochum have achieved a breakthrough in protein research. Using yeast, they have succeeded in making virtually the complete inventory of all the proteins in the mitochondria, the energy producers found in every cell.



Full text in ScienceDaily : http://www.sciencedaily.com/releases/2009/10/091015123602.htm

alpha-tocopherol beta-Oxidation Localized to Rat Liver Mitochondria

Free Radic Biol Med. 2009 Oct 8

Mustacich DJ, Leonard SW, Patel NK, Traber MG.
Linus Pauling Institute, Oregon State University, Corvallis, OR.

Keywords: dietary supplements, vitamin E (alpha-tocopherol), hepatic metabolism, microsomes, peroxisomes, trolox, alpha-CEHC, "mitochondrial role in alpha-tocopherol metabolism".

Cerebellar Contributions to Adaptive Control of Saccades in Humans

The Journal of Neuroscience, October 14, 2009, 29(41):12930-12939; doi:10.1523/JNEUROSCI.3115-09.2009

Minnan Xu-Wilson,1 Haiyin Chen-Harris,1 David S. Zee,2 and Reza Shadmehr1

1Departments of Biomedical Engineering and 2Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

Keywords: cerebellum, internal feedback correct, saccades, cerebellar damage, dysmetria.