Imaging of Mitochondrial Dynamics in Motor and Sensory Axons of Living Mice

Imaging of Mitochondrial Dynamics in Motor and Sensory Axons of Living Mice. Irene Bolea, Wen-Biao Gan, Giovanni Manfedi, Jordi Magrané, n: Anne N. Murphy and David C. Chan, Editor(s), Methods in Enzymology, Academic Press, 2014, Volume 547, Pages 97-110, ISSN 0076-6879, ISBN 9780128014158, http://dx.doi.org/10.1016/B978-0-12-801415-8.00006-0.

Poor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich's ataxia patient.

Poor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich's ataxia patient. Patil S, Lele V., Indian J Nucl Med. 2014 Oct;29(4):262-3. doi: 10.4103/0972-3919.142638.

Computational analysis of evolutionary and structural aspects of Cryptochromes and Frataxins.

Computational analysis of evolutionary and structural aspects of Cryptochromes and Frataxins.[Ph.D. thesis], Tosatto, Silvio C E, University
of Padova, 31 January 2014.

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Dr. Susan Perlman appeared on American Health Journal Nov 7to discuss Friedreich’s Ataxia

Dr. Susan Perlman appeared on American Health Journal Nov 7 to discuss Friedreich’s Ataxia.  (the section about Friedreich’s Ataxia starts at 15:39)

Dr. Susan Perlman appeared on American Health Journal this Friday to discuss Friedreich’s Ataxia (FA) along with one of her patients, Stephanie Magness. They educated viewers on the clinical aspects of the disease as well as daily life and clinical studies.

Suppression of Enhanced Physiological Tremor via Stochastic Noise: Initial Observations

Suppression of Enhanced Physiological Tremor via Stochastic Noise: Initial Observations. Trenado C, Amtage F, Huethe F, Schulte-Mönting J, Mendez-Balbuena I, Stuart N. Baker, Mark Baker, Marie-Claude Hepp-Reymond, Elias Manjarrez, Rumyana Kristeva; PLoS ONE 9(11): e112782. doi:10.1371/journal.pone.0112782

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Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP

Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP . Alok Pandey, Jayashree Pain, Arnab K. Ghosh, Andrew Dancis and Debkumar Pain; J. Biol. Chem. jbc.M114.610402. First Published on November 14, 2014, doi:10.1074/jbc.M114.610402

The experimental system as described here may help to define the biochemical basis of diseases that are associated with impaired Fe-S cluster biogenesis in mitochondria such as Friedreich's ataxia.

Mechanism Involved in the Blunted Anti-Oxidant Response in the Frataxin-Deficient Heart: Increased Nrf2 Degradation via both the Keap1 and GSK3β Pathway

Mechanism Involved in the Blunted Anti-Oxidant Response in the Frataxin-Deficient Heart: Increased Nrf2 Degradation via both the Keap1 and GSK3β Pathway. Amy Anzovino, Clare L. Hawkins, Michael L.H. Huang, Des R. Richardson; Free Radical Biology and Medicine, Volume 76, Supplement 1, November 2014, Page S46, ISSN 0891-5849, http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.402.

Transforming Our Approach to Translational Neuroscience: The Role and Impact of Charitable Nonprofits in Research

Transforming Our Approach to Translational Neuroscience: The Role and Impact of Charitable Nonprofits in Research. Cynthia Joyce, Neuron, Volume 84, Issue 3, 5 November 2014, Pages 526-532, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2014.10.030.

Friedreich Ataxia

Friedreich Ataxia. Massimo Pandolfo; Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (Fifth Edition). 2015, Pages 833–843

Keywords: Ataxia; Cardiomyopathy; Chromatin; Histone acetylation; Induced pluripotent stem cells; Iron–sulfur clusters; Mitochondria, Iron; Neurodegenerative diseases; Oxidative stress; Transgenic mice; Triplet repeat expansion

NEW TOOL: ClinRegs, an online database of country-specific clinical research regulatory information

NEW: ClinRegs, an online database of country-specific clinical research regulatory information . The National Institutes of Health (NIH)

ClinRegs is an online database of country-specific clinical research regulatory information designed to save time and effort in planning and implementing clinical research.