Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria

ScienceDaily (Oct. 15, 2009) — All of life is founded on the interactions of millions of proteins. These are the building blocks for cells and form the molecular mechanisms of life. The problem is that proteins are extremely difficult to study, particularly because there are so many of them and they appear in all sizes and weights. Now, Kris Gevaert from VIB/Ghent University and colleagues from the universities of Freiburg and Bochum have achieved a breakthrough in protein research. Using yeast, they have succeeded in making virtually the complete inventory of all the proteins in the mitochondria, the energy producers found in every cell.



Full text in ScienceDaily : http://www.sciencedaily.com/releases/2009/10/091015123602.htm

alpha-tocopherol beta-Oxidation Localized to Rat Liver Mitochondria

Free Radic Biol Med. 2009 Oct 8

Mustacich DJ, Leonard SW, Patel NK, Traber MG.
Linus Pauling Institute, Oregon State University, Corvallis, OR.

Keywords: dietary supplements, vitamin E (alpha-tocopherol), hepatic metabolism, microsomes, peroxisomes, trolox, alpha-CEHC, "mitochondrial role in alpha-tocopherol metabolism".

Cerebellar Contributions to Adaptive Control of Saccades in Humans

The Journal of Neuroscience, October 14, 2009, 29(41):12930-12939; doi:10.1523/JNEUROSCI.3115-09.2009

Minnan Xu-Wilson,1 Haiyin Chen-Harris,1 David S. Zee,2 and Reza Shadmehr1

1Departments of Biomedical Engineering and 2Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

Keywords: cerebellum, internal feedback correct, saccades, cerebellar damage, dysmetria.

Nutrition, Brain Aging, and Neurodegeneration

The Journal of Neuroscience, October 14, 2009, 29(41):12795-12801; doi:10.1523/JNEUROSCI.3520-09.2009

James Joseph,1 Greg Cole,2 Elizabeth Head,3 and Donald Ingram4

1USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, 2Geriatric Research, Education and Clinical Centers, Veterans Affairs Medical Center, and Department of Medicine, University of California, Los Angeles, Sepulveda, California 91343, 3University of Kentucky Sanders-Brown Center on Aging, Lexington, Kentucky 40536, and 4Pennington Biomedical Center, Baton Rouge, Louisiana 70808



Unfortunately we all know what is the FA, and these tips are not enough, but they are interesting.

Long-Term Safety and Tolerability of Idebenone in Friedreich's Ataxia Patients (MICONOS Extension)

Official Title: A Phase III Open-Label, Single-Group, Extension Study to Obtain Long-Term Safety and Tolerability Data of Idebenone in the Treatment of Friedreich's Ataxia Patients.

This study is currently recruiting participants.
Verified by Santhera Pharmaceuticals, October 2009
First Received: October 13, 2009

Sponsored by: Santhera Pharmaceuticals

ClinicalTrials.gov Identifier: NCT00993967

Stress ossidativo ed anomalie citoscheletriche nell’Atassia di Friedreich

Piemonte, Fiorella
Gaeta, Laura Maria
UNIVERSITÀ DEGLI STUDI DI ROMA "TOR VERGATA", FACOLTA' DI MEDICINA, DOTTORATO DI RICERCA IN BIOTECNOLOGIE MEDICHE E MEDICINA MOLECOLARE

Issue Date: 6-Aug-2009

Keywords: Atassia di Friedreich, glutatione, proteine glutationilate, citoscheletro, stress ossidativo, regolazione redox.

Link to full text: http://dspace.uniroma2.it/dspace/bitstream/2108/994/1/TESI+DI+DOTTORATO.pdf

A comparison of three measures of upper limb function in Friedreich ataxia.

J Neurol. 2009 Oct 13.
Corben LA, Tai G, Wilson C, Collins V, Churchyard AJ, Delatycki MB.
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Flemington Rd, Parkville, VIC, 3052, Australia.

Keywords: Friedreich Ataxia (FRDA), false negative results, upper limb function, the Nine Hole Peg Test (9HPT), Box and Blocks Test (BBT), Jebsen Taylor Hand Function Test (JTHFT),Friedreich Ataxia Functional Composite (FAFC) test, clinical studies, terapeutic trials, age at disease onset, disease duration, Friedreich Ataxia Rating Scale (FARS).

Antioxidants and other pharmacological treatments for Friedreich ataxia.

Cochrane Database Syst Rev. 2009 Oct 7;4:CD007791

Kearney M, Orrell RW, Fahey M, Pandolfo M.
General Practice, Irish College of General Practitioners, Dunlavin, County Wicklow, Ireland.

Keywords: Friedreich ataxia, autosomal recessive, neurological disorder, slurred speech, scoliosis, pes cavus, heart abnormalities, antioxidants, controlled trials, international Co-operative Ataxia Rating Scale (ICARS),left ventricular heart mass, magnetic resonance imaging, echocardiography, idebenone.

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Rao Muralikrishna Adibhatla, James Franklin Hatcher, Savita Khanna, Shrinivas K. Kulkarni, Pamela Maher, Cesare Mancuso, Stanley I. Rapoport, Mark Smith, Bobby Thomas, Tatsurou Yagami. Antioxidants & Redox Signaling. -Not available-, ahead of print. doi:10.1089/ars.2009.2668.

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. William S. Middleton Veterans Affairs Hospital, Madison, Wisconsin.

Keywords: Reactive oxygen species (ROS), oxidative phosphorylation, NAD(P)H oxidases, arachidonic acid oxidative metabolism, endogenous antioxidant defenses, Nrf2/ARE, Oxidative stress, lipids, cell death, oxidized phospholipids, 4-hydroxynonenal, 4-oxo-2-nonenal, acrolein, neurodegenerative diseases (AD, ALS, bipolar disorder, epilepsy, Friedreich's ataxia, HD, MS, NBIA, NPC, PD, peroxisomal disorders, schizophrenia, Wallerian degeneration, Zellweger syndrome), CNS traumas (stroke, TBI, SCI), free iron, Fenton reaction, cholesterol, lipid oxidation/peroxidation.

Risk/Benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions.

Hemoglobin. 2009;33(5):386-97.

Kontoghiorghes GJ, Efstathiou A, Kleanthous M, Michaelides Y, Kolnagou A.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.

Keywords: oxidative stress, brain, heart, liver, kidneys, classical antioxidants, deferiprone, mobilizing labile iron and copper, free radicals, high therapeutic index, tissue penetration, rapid iron binding, clearance, iron complex, toxicity, cardiomyopathy, thalassemia, diabetic nephropathy, glomerulonephritis, kidney disease, Friedreich's Ataxia, Fanconi Anemia, deferoxamine (DFO), deferasirox (DFRA).