Stem Cell Research News From Medical News Today, Article Date: 01 Feb 2011 - 4:00 PST
Researchers at Johns Hopkins have found a better way to create induced pluripotent stem (iPS) cells-adult cells reprogrammed with the properties of embryonic stem cells-from a small blood sample. This new method, described last week in Cell Research, avoids creating DNA changes that could lead to tumor formation. read more....
Tuesday, February 1, 2011
Sunday, January 30, 2011
Medtronic Announces Global Launch Of The CD HORIZON(R) SOLERA™ Spinal System
Medical News Today, Article Date: 30 Jan 2011 - 0:00 PST, Source: Spine Business, Medtronic
Continuing a stream of recent advancements for stabilization of the spine, Medtronic, Inc. (NYSE: MDT) announced both the release of its CD HORIZON® SOLERA™ Spinal System in the U.S. and a limited market release in Japan. This product launch is part of the CD HORIZON® family of fixation devices, designed to provide spinal stabilization and correction as an adjunct to fusion in patients suffering from painful and function-limiting disorders of the middle and lower back. read full text....
Further information:
Continuing a stream of recent advancements for stabilization of the spine, Medtronic, Inc. (NYSE: MDT) announced both the release of its CD HORIZON® SOLERA™ Spinal System in the U.S. and a limited market release in Japan. This product launch is part of the CD HORIZON® family of fixation devices, designed to provide spinal stabilization and correction as an adjunct to fusion in patients suffering from painful and function-limiting disorders of the middle and lower back. read full text....
Further information:
Friday, January 28, 2011
Detection of interruptions in the GAA trinucleotide repeat expansion in the FXN gene of Friedreich ataxia
BioTechniques, Vol. 50, No. 3, March 2011
Timothy P. Holloway*1,2, Simone M. Rowley*1, Martin B. Delatycki1,3, 4, and Joseph P. Sarsero1,2, 3
1Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
2Cell and Gene Therapy, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
3Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia
4Department of Clinical Genetics, Austin Health, Heidelberg, Victoria, Australia
"simple and rapid PCR- and restriction enzyme–based assay", "Interruptions in the GAA repeat may serve to alleviate the inhibitory effects of the GAA expansion on FXN gene expression and to decrease pathogenicity"
Full text pdf
Timothy P. Holloway*1,2, Simone M. Rowley*1, Martin B. Delatycki1,3, 4, and Joseph P. Sarsero1,2, 3
1Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
2Cell and Gene Therapy, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
3Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia
4Department of Clinical Genetics, Austin Health, Heidelberg, Victoria, Australia
"simple and rapid PCR- and restriction enzyme–based assay", "Interruptions in the GAA repeat may serve to alleviate the inhibitory effects of the GAA expansion on FXN gene expression and to decrease pathogenicity"
Full text pdf
Thursday, January 27, 2011
Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex
PLoS ONE 6(1): e16199. doi:10.1371/journal.pone.0016199
Stéphane Schmucker1,2,3,4,5, Alain Martelli1,2,3,4,5, Florent Colin1,2,3,4,5, Adeline Page1,2,3,4, Marie Wattenhofer-Donzé1,2,3,4,5, Laurence Reutenauer1,2,3,4,5, Hélène Puccio1,2,3,4,5*
1 Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France, 2 Inserm U596, Illkirch, France, 3 CNRS UMR7104, Illkirch, France, 4 Université de Strasbourg, Strasbourg, France, 5 Chaire de Génétique Humaine, Collège de France, Illkirch, France
OPEN ACCESS
Conclusions/Significance
Our results suggest that the interaction of frataxin with the core ISCU/NFS1/ISD11 complex most likely defines the essential function of frataxin. Our results provide new elements important for further understanding the early steps of de novo Fe-S cluster biosynthesis
FULL TEXT PDF
Stéphane Schmucker1,2,3,4,5, Alain Martelli1,2,3,4,5, Florent Colin1,2,3,4,5, Adeline Page1,2,3,4, Marie Wattenhofer-Donzé1,2,3,4,5, Laurence Reutenauer1,2,3,4,5, Hélène Puccio1,2,3,4,5*
1 Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France, 2 Inserm U596, Illkirch, France, 3 CNRS UMR7104, Illkirch, France, 4 Université de Strasbourg, Strasbourg, France, 5 Chaire de Génétique Humaine, Collège de France, Illkirch, France
OPEN ACCESS
Conclusions/Significance
Our results suggest that the interaction of frataxin with the core ISCU/NFS1/ISD11 complex most likely defines the essential function of frataxin. Our results provide new elements important for further understanding the early steps of de novo Fe-S cluster biosynthesis
FULL TEXT PDF
The Mitochondrial Connection in Auditory Neuropathy.
Audiol Neurotol 2011;16:398-413 (DOI: 10.1159/000323276)
Cacace AT, Pinheiro JM.
Department of Communication Sciences and Disorders, Wayne State University, Detroit, Mich., USA.
Keywords: Auditory brainstem responses, Auditory neuropathy, Charcot-Marie-Tooth disease, Autosomal dominant optic atrophy, Cochlear microphonics, Friedreich’s ataxia, Hyperbilirubinemia, Respiratory chain, Leber’s hereditary optic neuropathy, Mitochondria, Otoacoustic emissions.
Cacace AT, Pinheiro JM.
Department of Communication Sciences and Disorders, Wayne State University, Detroit, Mich., USA.
Keywords: Auditory brainstem responses, Auditory neuropathy, Charcot-Marie-Tooth disease, Autosomal dominant optic atrophy, Cochlear microphonics, Friedreich’s ataxia, Hyperbilirubinemia, Respiratory chain, Leber’s hereditary optic neuropathy, Mitochondria, Otoacoustic emissions.
Analysis of nucleosome positioning determined by DNA helix curvature in the human genome
Hongde Liu, Xueye Duan, Shuangxin Yu and Xiao Sun.
BMC Genomics 2011, 12:72doi:10.1186/1471-2164-12-72
Published: 27 January 2011
OPEN ACCESS
Full text PDF
BMC Genomics 2011, 12:72doi:10.1186/1471-2164-12-72
Published: 27 January 2011
OPEN ACCESS
Full text PDF
Saturday, January 22, 2011
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
Nature Reviews Molecular Cell Biology 12, 79-89 (February 2011) | doi:10.1038/nrm3043
Chris Jopling1, Stephanie Boue1 & Juan Carlos Izpisua Belmonte1,2
1. Center of Regenerative Medicine in Barcelona. 2. Salk Institute for Biological Studies, La Jolla, California.
Chris Jopling1, Stephanie Boue1 & Juan Carlos Izpisua Belmonte1,2
1. Center of Regenerative Medicine in Barcelona. 2. Salk Institute for Biological Studies, La Jolla, California.
Friday, January 21, 2011
[The various forms of left ventricular hypertrophy : Diagnostic value of echocardiography.]
Herz. 2011 Jan 20. [Epub ahead of print]
Article in German
Weidemann F, Störk S, Herrmann S, Ertl G, Niemann M.
Medizinische Klinik und Poliklinik I, Herz- und Kreislaufzentrum, Universität Würzburg, Oberdürbacherstr. 6, 97080, Würzburg, Deutschland
Keywords:Left ventricular hypertrophy, echocardiography, advanced imaging modalities, hypertrophic obstructive cardiomyopathy, systolic function, thickened septum, concentric left ventricular hypertrophy, Friedreich cardiomyopathy, left ventricular hypertrophy, sparkling granular texture, early diagnosis.
Article in German
Weidemann F, Störk S, Herrmann S, Ertl G, Niemann M.
Medizinische Klinik und Poliklinik I, Herz- und Kreislaufzentrum, Universität Würzburg, Oberdürbacherstr. 6, 97080, Würzburg, Deutschland
Keywords:Left ventricular hypertrophy, echocardiography, advanced imaging modalities, hypertrophic obstructive cardiomyopathy, systolic function, thickened septum, concentric left ventricular hypertrophy, Friedreich cardiomyopathy, left ventricular hypertrophy, sparkling granular texture, early diagnosis.
Tuesday, January 18, 2011
Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases
BMC Systems Biology 2011, 5:6doi:10.1186/1752-0509-5-6
Shiek S.S.J Ahmed, Abdul R. Ahameethunisa, Winkins Santosh, Srinivasa Chakravarthy and Suresh Kumar
OPEN ACCESS
This study improves the understanding of the complex interactions that occur between neurological and psychiatric diseases with aging, which lead to determine the diagnostic markers. Also, the disease-disease association results could be helpful to determine the symptom relationships between neurological and psychiatric diseases. Together, our study presents many research opportunities in post-genomic biomarker development.
"this approach provides the additional information that PDHB is not only associated with Parkinson’s disease but also associated with Athetosis and Friedreich Ataxia"
FULL TEXT PDF
Shiek S.S.J Ahmed, Abdul R. Ahameethunisa, Winkins Santosh, Srinivasa Chakravarthy and Suresh Kumar
OPEN ACCESS
This study improves the understanding of the complex interactions that occur between neurological and psychiatric diseases with aging, which lead to determine the diagnostic markers. Also, the disease-disease association results could be helpful to determine the symptom relationships between neurological and psychiatric diseases. Together, our study presents many research opportunities in post-genomic biomarker development.
"this approach provides the additional information that PDHB is not only associated with Parkinson’s disease but also associated with Athetosis and Friedreich Ataxia"
FULL TEXT PDF
Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy
Genome Med 2010, 2:91 doi:10.1186/gm212
Rosamaria Santarelli, Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padua
Keywords: Auditory neuropathy (AN), disruption of auditory nerve activity, impairment of speech perception, hearing loss, abnormality of auditory brainstem potentials, preserved outer hair-cell activities, multisystem involvement, peripheral and optic neuropathies, abnormal cochlear potentials have been recorded from patients, genetically based auditory neuropathies, molecular mechanisms.
Rosamaria Santarelli, Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padua
Keywords: Auditory neuropathy (AN), disruption of auditory nerve activity, impairment of speech perception, hearing loss, abnormality of auditory brainstem potentials, preserved outer hair-cell activities, multisystem involvement, peripheral and optic neuropathies, abnormal cochlear potentials have been recorded from patients, genetically based auditory neuropathies, molecular mechanisms.
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