Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies

Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies. Jin Hae Kim, Jameson R. Bothe, T. Reid Alderson, John L. Markley, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Available online 22 November 2014, ISSN 0167-4889, http://dx.doi.org/10.1016/j.bbamcr.2014.11.020.

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Therapeutic strategies in mitochondrial disorders

Therapeutic strategies in mitochondrial disorders . Josef Finsterer, P.S. Bindu, Pediatric Neurology, Available online 15 November 2014, ISSN 0887-8994, http://dx.doi.org/10.1016/j.pediatrneurol.2014.06.023.

Despite the lack of a causal treatment for mitochondrial disorders, a nihilistic attitude towards the treatment issue is not justified. A number of studies are under way to search for causal approaches and highly effective symptomatic measures are available.

Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast

Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast . Kartik A. Shah, Ryan J. McGinty, Vera I. Egorova, Sergei M. Mirkin, Cell Reports, Available online 20 November 2014, ISSN 2211-1247, http://dx.doi.org/10.1016/j.celrep.2014.10.048.

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The Future of Neuroepigenetics in the Human Brain

The Future of Neuroepigenetics in the Human Brain. Amanda Mitchell, Panos Roussos, Cyril Peter, Nadejda Tsankova, Schahram Akbarian, Chapter Eight - In: Schahram Akbarian and Farah Lubin, Editor(s), Progress in Molecular Biology and Translational Science, Academic Press, 2014, Volume 128, Pages 199-228, ISSN 1877-1173, ISBN 9780128009772, http://dx.doi.org/10.1016/B978-0-12-800977-2.00008-5.

Imaging of Mitochondrial Dynamics in Motor and Sensory Axons of Living Mice

Imaging of Mitochondrial Dynamics in Motor and Sensory Axons of Living Mice. Irene Bolea, Wen-Biao Gan, Giovanni Manfedi, Jordi Magrané, n: Anne N. Murphy and David C. Chan, Editor(s), Methods in Enzymology, Academic Press, 2014, Volume 547, Pages 97-110, ISSN 0076-6879, ISBN 9780128014158, http://dx.doi.org/10.1016/B978-0-12-801415-8.00006-0.

Poor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich's ataxia patient.

Poor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich's ataxia patient. Patil S, Lele V., Indian J Nucl Med. 2014 Oct;29(4):262-3. doi: 10.4103/0972-3919.142638.

Computational analysis of evolutionary and structural aspects of Cryptochromes and Frataxins.

Computational analysis of evolutionary and structural aspects of Cryptochromes and Frataxins.[Ph.D. thesis], Tosatto, Silvio C E, University
of Padova, 31 January 2014.

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Dr. Susan Perlman appeared on American Health Journal Nov 7to discuss Friedreich’s Ataxia

Dr. Susan Perlman appeared on American Health Journal Nov 7 to discuss Friedreich’s Ataxia.  (the section about Friedreich’s Ataxia starts at 15:39)

Dr. Susan Perlman appeared on American Health Journal this Friday to discuss Friedreich’s Ataxia (FA) along with one of her patients, Stephanie Magness. They educated viewers on the clinical aspects of the disease as well as daily life and clinical studies.

Suppression of Enhanced Physiological Tremor via Stochastic Noise: Initial Observations

Suppression of Enhanced Physiological Tremor via Stochastic Noise: Initial Observations. Trenado C, Amtage F, Huethe F, Schulte-Mönting J, Mendez-Balbuena I, Stuart N. Baker, Mark Baker, Marie-Claude Hepp-Reymond, Elias Manjarrez, Rumyana Kristeva; PLoS ONE 9(11): e112782. doi:10.1371/journal.pone.0112782

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Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP

Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP . Alok Pandey, Jayashree Pain, Arnab K. Ghosh, Andrew Dancis and Debkumar Pain; J. Biol. Chem. jbc.M114.610402. First Published on November 14, 2014, doi:10.1074/jbc.M114.610402

The experimental system as described here may help to define the biochemical basis of diseases that are associated with impaired Fe-S cluster biogenesis in mitochondria such as Friedreich's ataxia.