Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

Nature Medicine 15, 1215 - 1218 (2009)
Published online: 13 September 2009 | doi:10.1038/nm.2025

Yong Hong Chen¹, Michael Chang² & Beverly L Davidson^1,3

1. Department of Internal Medicine, Iowa City, Iowa, USA.
2. Departments of Molecular Physiology & Biophysics, Iowa City, Iowa, USA.
3. Department of Neurology, University of Iowa, Iowa City, Iowa, USA.

Keywors: Brain vasculature,  neural cells, microvessel,  enzyme replacement therapy, central nervous system (CNS), endothelia,  neurons,  glia, adeno-associated virus (AAV),  biodistribution.