AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development

The Journal of Neuroscience, December 9, 2009, 29(49):15366-15374; doi:10.1523/JNEUROSCI.5188-09.2009

Emmanuelle Bitoun,^1,2 * Mattéa J. Finelli,^1,2 * Peter L. Oliver,^1,2 Sheena Lee,¹ and Kay E. Davies^1,2
1Medical Research Council Functional Genomics Unit, and ²Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom

 Keywords:  insulin-like growth factor 1 (IGF-1), cerebellar ataxia,  neuronal cell death, targeted for therapy,  Purkinje cell (PC) death, cerebellum, transcriptional cofactor.