Wednesday, February 17, 2010

FRIEDREICH'S ATAXIA: MOLECULAR MECHANISMS, REDOX CONSIDERATIONS AND THERAPEUTIC OPPORTUNITIES

Antioxid Redox Signal. 2010 Feb 16.

Santos R, Lefevre S, Sliwa D, Seguin A, Camadro JM, Lesuisse E.
Institut Jacques Monod, Mitochondria, Metals and Oxidative Stress Laboratory, Bât.Buffon, 15 rue Hélène Brion, Paris, France, 75013, +331 57 27 80 28, +331 57 27 81 01; santos.renata@ijm.univ-paris-diderot.fr.

Keywords: Mitochondrial dysfunction, oxidative damage, neurodegenerative diseases,  Alzheimer's,  Parkinson's,  Friedreich's ataxia (FRDA),  GAA trinucleotide repeat expansion, FXN,  frataxin,  respiration, iron-sulfur cluster assembly, iron homeostasis, maintenance of the redox status, therapeutic approaches.

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