Tuesday, April 27, 2010

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation

J Clin Invest. doi:10.1172/JCI40000.
Bermans J. Iskandar1, Elias Rizk1, Brenton Meier1, Nithya Hariharan1, Teodoro Bottiglieri2, Richard H. Finnell3, David F. Jarrard4, Ruma V. Banerjee5, J.H. Pate Skene6, Aaron Nelson1, Nirav Patel1, Carmen Gherasim5, Kathleen Simon1, Thomas D. Cook7 and Kirk J. Hogan8
1Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin, USA.
2Baylor Research Institute, Institute of Metabolic Disease, Dallas, Texas, USA.
3Texas Institute for Genomic Medicine, Houston, Texas, USA.
4Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA.
5Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
6Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
7Department of Biostatistics and
8Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin, USA. 

 Keywords: folate supplementation, neurodegenerative and neuropsychiatric disorders, afferent spinal neurons, DNA methylation, axonal regeneration, epigenetic mechanism contributing to neurorepair, promote regeneration.



See the related Commentary:

J. Clin. Invest. doi:10.1172/JCI40764.

Neuronal injury: folate to the rescue?

Golo Kronenberg, Matthias Endres

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