PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

Antioxidants & Redox Signaling. Ahead of print. doi:10.1089/ars.2009.2940.
Zhongbing Lu, Xin Xu, Xinli Hu, John Fassett, Guangshuo Zhu, Yi Tao, Jingxin Li, Yimin Huang, Ping Zhang, Baolu Zhao, Yingjie Chen.

Keywords: Mitochondria, reactive oxygen species (ROS, heart, Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α), SOD2, and thioredoxin (Trx2), 3’-nitrotyrosine, 4-hydroxynonenal, TAC-induced myocardial oxidative stress, hypertrophy,dysfunction.