Sunday, October 17, 2010

Induced pluripotency: history, mechanisms, and applications

Genes & Dev. 2010. 24: 2239-2263, doi: 10.1101/gad.1963910
Matthias Stadtfeld, Konrad Hochedlinger

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The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced expression of a few embryonic transcription factors.

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