Activation of mitochondrial energy metabolism protects against cardiac failure.

Aging (Albany NY). 2010 Nov 16.

Schulz TJ, Westermann D, Isken F, Voigt A, Laube B, Thierbach R, Kuhlow D, Zurse K, Schomburg L, Pfeiffer AF, Tschöpe C, Ristow M.
Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany.

Keywords: Cardiac failure, impaired energy homeostasis in the heart, Mitochondrial metabolism, over-expressing the mitochondrial protein frataxin, iron-sulfur-cluster biogenesis, mitochondrial electron flux, stress defense mechanisms, cardiomyopathy, insulin/IGF-1 signaling cascade, protein kinase B, Akt, glycogen synthase kinase 3.