Monday, December 6, 2010

Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells

J Biol Chem. 2010 Dec 2. [Epub ahead of print]

Kumari D, Biacsi RE, Usdin K., NIH, United States.

Keywords: Expansion of a GAA·TTC-repeat, first intron, frataxin (FXN) gene, mRNA deficit, Friedreich ataxia (FRDA), DNA methylation, histone modifications, chromatin immuno-precipitation, chromatin, RNA polymerase II, histone H3 trimethylated on lysine 4, trimethylated H3K36.

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