Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses

Antioxidants & Redox Signaling (14, 000–000). -Online Ahead of Print: February 20, 2011-. doi:10.1089/ars.2010.3568.

Francesc X. Soriano, Frédéric Léveillé, Sofia Papadia, Karen F.S. Bell, Clare Puddifoot, Giles E. Hardingham.

Centre for Integrative Physiology, University of Edinburgh

Keywords: Transcriptional coactivators and corepressors, multiple targets, coactivator peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α, Huntington's, antioxidant defenses, mitochondrial biogenesis, retinoic acid and thyroid hormone receptors (SMRT), implications for neuronal viability.