Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H2O2*

Journal of Neurochemistry, 2011, DOI: 10.1111/j.1471-4159.2011.07290.x Accepted Article (Accepted, unedited articles published online for future issues)

David Cantu 1,3, Ruth E. Fulton 2, Derek A. Drechsel 2, Manisha Patel 1,2

1 Graduate Program in Neuroscience, 2 Department of Pharmaceutical Sciences, University of Colorado, 3 Department of Neuroscience, Tufts University School of Medicine

Keywords: mitochondrial aconitase, oxidative stress, paraquat, neurotoxicity, hydrogen peroxide, iron, cellular metabolism