Rapamycin reduces oxidative stress in frataxin deficient yeast cells

Mitochondrion, Article in Press, Accepted Manuscript, doi:10.1016/j.mito.2011.07.001

Carlo M.T. Marobbioa, 1, Isabella Pisanoa, 1, Vito Porcellia, Francesco M. Lasorsab and Luigi Palmieria, b.

a Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco-Biology, University of Bari, Via E. Orabona 4, 70125 Bari, Italy
b CNR Institute of Biomembranes and Bioenergetics, Via Orabona 4, 70125 Bari, Italy

Keywords: Friedreich ataxia (FRDA), frataxin, mitochondria, antioxidant protection, mitochondrial damage, antioxidant idebenone, yeast frataxin knock-out model, iron accumulation, iron-sulphur cluster defects, high sensitivity to oxidative stress, reactive oxygen species (ROS), rapamycin, TOR kinases inhibitor, autophagy, mitophagy.