Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection. Pablo M. Arce, Ruth Goldschmidt, Omar M. Khdour, Manikandadas M. Madathil, Jennifer Jaruvangsanti, Sriloy Dey, David M. Fash, Jeffrey S. Armstrong, Sidney M. Hecht. Bioorganic & Medicinal Chemistry, Available online 14 July 2012. DOI: http://dx.doi.org/10.1016/j.bmc.2012.07.005

Keywords: pyridinol analogues, neuroprotective, idebenone, antioxidants, mitochondrial function, electron transport chain, Reactive oxygen species.