Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration

Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration. Antonio Uccelli, Experimental Neurology, Available online 4 February 2013.

The concept of repair of the nervous system by adult stem cells has recently evolved from the original hypothesis that tissue regeneration could have been achieved through stem cells differentiation into neural cells to the current vision that they act mainly by means of paracrine mechanisms. Is preferable the stem cells transplantation or the administration of their secreted factors?.

Keywords: Mesenchymal stem cells, microglia, chemokines, neuroprotection, immunomodulation