Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and

Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and. Antonio Lavecchia, Carmen Di Giovanni, Carmen Cerchia, Annapina Russo, Giulia Russo, Ettore Novellino; J. Med. Chem., Just Accepted Manuscript. DOI: 10.1021/jm3017199

Keywords: Friedreich ataxia (FRDA), frataxin, ubiquitin–proteasomal pathway, residue K147, potential ubiquitin-binding domain.