Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by Vitamin B3

Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by Vitamin B3 . Ping K. Chan, Raul Torres, Cihangir Yandim, Pui P. Law, Sanjay Khadayate, Marta Mauri, Crina Grosan, Nadine Chapman-Rothe, Paola Giunti, Mark Pook, and Richard Festenstein. Hum. Mol. Genet. first published online March 7, 2013 doi:10.1093/hmg/ddt115

Keywords: triplet repeat sequence (GAA.TTC), transcriptional repression, Frataxin gene (FXN), Friedreich's ataxia (FRDA), heterochromatinization, H3K9me3, H3K27me3, class III HDAC inhibitor vitamin B3 (nicotinamide), H3 and H4 histone acetylations, nicotinamide.