Synthesis of Benzoquinone Antioxidants and a Bleomycin Disaccharide Library

Synthesis of Benzoquinone Antioxidants and a Bleomycin Disaccharide Library. Mathilakathu Madathil, Manikandadas (Author) / Hecht, Sidney M (Advisor) / Rose, Seth (Committee member) / Woodbury, Neal (Committee member) / Arizona State University (Publisher).; Doctoral Dissertation, ASU Electronic Dissertations and Theses (2013)

The synthesized 5-amino-3-tridecyl-1,4-benzoquinone antioxidants were tested for their ability to protect Friedreich's ataxia (FRDA) lymphocytes from induced oxidative stress. Some of the analogues synthesized conferred cytoprotection in a dose-dependent manner in FRDA lymphocytes at micromolar concentrations.


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