Energy failure—does it contribute to neurodegeneration?

Energy failure—does it contribute to neurodegeneration?. Divya Pathak, Amandine Berthet and Ken Nakamura; Annals of Neurology, Accepted manuscript online: 22 AUG 2013 04:13PM EST | DOI: 10.1002/ana.24014

Energy failure has never been directly demonstrated in affected neurons in these diseases, nor has it been proved to produce degeneration in disease models but energy failure from mitochondrial dysfunction is proposed to be a central mechanism leading to neuronal death in a range of neurodegenerative diseases.