Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein

Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein . Stefka Mincheva-Tasheva, Elia Obis, Jordi Tamarit and Joaquim Ros; Hum. Mol. Genet. (2013) doi: 10.1093/hmg/ddt576. First published online: November 15, 2013.

Keywords: Friedreich ataxia, mitochondrial protein frataxin, dorsal root ganglion (DRG), mitochondrial membrane potential decrease, neurite degeneration, apoptotic cell death, free intracellular Ca2+ levels, Ca2+-mediated signaling pathways, altered calcium homeostasis, BH4, Bcl-xL.