Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson’s disease.

Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson’s disease. Gonzalo-Gobernado R, Calatrava-Ferreras L, Reimers D, Herranz AS, Rodríguez-Serrano M, Miranda C, Jiménez-Escrig A, Díaz-Gil JJ, Bazán E; PLoS One. 2013 Jul 4;8(7):e67771.

Actually, we intend to determine whether LGF which has a demonstrated antioxidant and neuroprotective capability, could be a useful therapy for Friedreich’ ataxia (FA). Results show that LGF treatment stimulates frataxin immunoreactivity and frataxin protein expression in CNS and heart of FXNtm1MknTg (FXN)YG8Pook FA transgenic mice. Besides, LGF significantly improves oxidative stress in squeletal muscle, suggesting that LGF could be a promising treatment for FA.

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